Description
PEG-MGF is a polyethylene glycol conjugate of MGF, the 24-residue C-terminal E-domain peptide of the IGF-1 Ec splice variant. The peptide carries an additional C-terminal cysteine residue that serves as the site for PEG attachment, and the PEG is joined through a succinimidyl linker.
PEGylation is a standard bioconjugation approach used to increase hydrodynamic radius and reduce renal clearance of small peptides. This material is supplied as a characterized reference conjugate for non-clinical laboratory work, such as size exclusion and reverse-phase chromatographic characterization of PEG-peptide conjugates, analytical method development for PEGylated species, conjugation efficiency and free-peptide determination, IGF-1 receptor binding assays, and in vitro myoblast culture studies.
Chemical Information
- Peptide sequence: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
- Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉, ~2867 g/mol
- Molecular Weight: 2867.21
- PubChem SID: 178101669
- Physical Form: Lyophilized powder
- CAS Number: 62031-54-3
Storage & Handling
Store lyophilized powder at −20 °C, protected from light. Avoid moisture and repeated freeze-thaw cycles. Note that this conjugate contains a free or linked cysteine thiol and is subject to oxidation and disulfide formation; handle and store accordingly. Handle in accordance with standard laboratory safety practices.